The OPIOSTOP treatment
process in detail



PLACE OF TREATMENT: Hospitals fmi AG, Interlaken Hospital



The actual withdrawal at Interlaken Hospital takes about 2.5 days. You then spend another two days in a hotel in Interlaken for the post-treatment phase.  



Some patients prefer or require in-patient psychiatric care after withdrawal instead of the hotel phase due to their medical history and accompanying illnesses. This can take be organised at Interlaken Hospital as an inpatient in the psychiatric crisis intervention centre or close to the patient's place of residence.



Dr Patricia Manndorff
Head Physician, Institute for Anaesthesia and Intensive Care Medicine, Interlaken Hospital 
FMH Specialist for Anaesthesiology, Anaesthesiological Intensive Care Medicine


Dr Thomas Ihde
Head Physician, Psychiatric Services, Hospitals fmi AG
FMH Psychiatry and Psychotherapy



The nursing team consists exclusively of specialists with a background in anaesthesia, intensive care and ward nursing, all of whom have received training in OPIOSTOP.

Information and
medical history
Before the withdrawal

You will receive detailed information about the procedure from Dr  P. Manndorff and her team prior to the treatment, during the course of which all your outstanding questions will be addressed. All the substances you have taken will then be listed in detail in your medical history. The anaesthesia procedure will also take into account any secondary diseases, drug intolerances or allergies and potential risks. Your motivation for undergoing the treatment and any concomitant psychiatric ailments and stumbling blocks will be discussed in a psychiatric screening. Your psychosocial background, important biographical data and resources in your environment for follow-up treatment will also be taken down.

Final consultation
Day 0

On the day prior to your admission to hospital, you will have a final consultation at Interlaken Hospital with Dr Patricia Manndorff and, optionally, with the specialist general practitioner. A final health check and assessment of your suitability will be conducted prior to the procedure. If you live a long way away, you will then check into a hotel in Interlaken for the first night. Your last meal before the procedure will be at 6 p.m.

Safe withdrawal
under anaesthesia
Day 1

You will be admitted to Interlaken Hospital at 7 a.m. in a sober state. There then follows a phase which lasts until 12 noon, during which your organ systems are calmed by regular medication and prepared for the coming withdrawal.


At 12:00 noon you will be transferred to the intensive care unit, where the anaesthesia will be initiated. The physical withdrawal then takes place, in the form of two to three naltrexone cycles, individually dosed to you over a period of 5-6 hours. 


During the anaesthesia and withdrawal, your clinical condition and changes in your values are constantly monitored, observed and reassessed. The treatment is tailored to your specific requirements and continuously evaluated. While under anaesthesia, withdrawal symptoms resulting from the body's stress response (norepinephrine) are actively treated to ensure that blood pressure, heart rate and respiratory rate remain within the normal range. The treatment is very safe: Dr P. Manndorff and the qualified care specialists remain at your bedside at all times.


The anaesthesia is concluded at around 6 p.m. Following the procedure, you will be monitored in the intensive care unit for a further two hours, during which time you will be supervised by the intensive care or anaesthesia team.
Dr Patricia Manndorff will continuously monitor your progress during this period.

You will be transferred back to the general ward at around 8 p.m. and will be accompanied by a staff member sitting at your bedside during the night. This makes it possible for gastrointestinal symptoms or restlessness to be treated immediately. The head of the anaesthesia team and Dr Patricia Manndorff will be on call for you overnight. You will enjoy the safety that a regional medical centre offering every medical and nursing service around the clock is able to provide.

Rest and relaxation
Day 2

The second day is devoted to rest and recuperation and treating any gastrointestinal problems, which are a common occurrence. You will be able to resume drinking and eating and may engage in short strolls. From the afternoon onwards, you may receive visits from relatives or friends. Should you have any mental health problems, we will arrange consultation with one of the doctors from the psychiatric clinic.

Transfer to hotel
Day 3

You will leave the hospital around midday and, accompanied by a friend or relative, will check back into your booked hotel in Interlaken. The accompanying person is required to motivate you to engage in physical and mental activities as quickly as possible. Such activities accelerate the production of endorphins and therefore your well-being, as they make it possible for a balance between opiate and receptor to occur more quickly. The medical responsibility for further treatment now passes from Dr P. Manndorff to the specialist general practitioner. He or she will visit you during the course of the day and call you for a telephone consultation in the evening.

Remaining active
Day 4

Be as active as possible on this day. In the morning and evening you will receive a telephone call from your specialist general practitioner and you will also be visited by him or her during the course of the day.

Final visit
Day 5

In the morning you will again receive a call from your specialist general practitioner and will receive your final visit from him or her at your hotel or Interlaken Hospital at around midday. You can then head home.

Recovery at home
Days 6 - 14

Please take at least two weeks off for the treatment. You will initially feel quite weak, you will not get sufficient sleep and will feel very sensitive, as feelings, sensations, smell and taste will be experienced in a completely different way after your withdrawal. After two weeks, you will have stabilised to a sufficient degree to be able to return to work.

Follow-up care
From day 15

After your withdrawal, you will attend scheduled follow-up examinations by your general practitioner or Dr P. Manndorff. At the outset, the follow-up examinations will be at regular intervals, then every two to three months as required. The dose of naltrexone must be taken daily and will be slowly reduced from the 12th month onwards. The medication can generally be stopped 18 months after withdrawal. You must follow the instructions that your specialist general practitioner gives you regarding the use of naltrexone to the letter or you will jeopardise the success of the treatment. The treatment is only concluded when you are no longer required to take naltrexone. Naltrexone is not addictive and is used to treat the pre-existing addiction. The drug is usually supplied on a repeat prescription and may be carried within the EU without any problems if you travel abroad.


Spitäler fmi AG, Interlaken Hospital
Weissenaustrasse 27
3800 Unterseen

Tel. +41 33 826 26 26

© 2019 OPIOSTOP / Hospitals fmi AG